Nowadays, especially in the pharmaceutical
industry, the need for Ultra Fast LC is still
growing due to the continuous demand for high
throughput analysis in research & development
and quality control. Often, Ultra Fast LC
methods are required with cycle times of 2
minutes or less. In order to enhance speed and
chromatographic performance short columns with
small particles have been used together with
high flow rates and at high pressure.
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Especially for these Ultra Fast LC methods, YMC
introduced YMC-UltraHT Pro C18 2 μm, which
ideally matches the latest instrumentation
technology for “extra” high pressure application
e.g. with Agilent 1200™ series or Waters Acquity
UPLC™.
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As a column and bulk media supplier with many
years of practical chromatographic experience,
YMC found unacceptable that the use of novel
separation media is often limited to dedicated
equipment only – particularly with regard to the
large installed base of “conventional” HPLC
systems with a standard pressure rating of 5800
psi (400 bar), 40 MPa. For this reason,
specifications for YMC-UltraHT Pro C18 are set
to provide powerful chromatographic improvements
concerning velocity and resolution also under
conventional operating conditions.
Since YMC-UltraHT Pro C18 provides a
substantially lower pressure drop than most
competitive 2 μm or sub-2 μm media, high flow
rates can be achieved without generating
excessive back pressure and without the need for
specialized equipment.
For effective high throughput separations,
YMC offers a wide range of high performance HPLC
columns which allow Ultra Fast analytical HPLC
with conventional equipment. Due to the down-scalablility
of the majority of YMC’s stationary phases, the
time needed for a single analysis can so be
reduced to less than 60 seconds, depending on
the sample conditions. |
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YMC-UltraHT Pro C18
Particles Spherical, ultra-pure silica, 2 μm
particle size, 12 nm pore size
Bonded phase C18, endcapped
Column Size 50 x 2.0 mm i.d.
pH range pH 2 - 8
part number: AS12S020502WT |
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The application of HPLC to biologically relevant
separations is an existing and rapidly growing
field. YMC-UltraHT Pro C18 provides outstanding
chromatgraphic performance, which is more than
capable of meeting the challenge of peptide
mapping, where a large number of peptide
fragments are generated from enzymatic
digestion. |
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Features of Packing Material |
When starting to focus on Ultra Fast LC through
the use of small particles, very high back
pressures have to be considered and a balance
sought. The extensive experience in silica
production enables YMC to provide small
particles with an extremely narrow particle size
distribution which results in low back
pressures.
YMC’s UltraHT Pro C18 columns offer outstanding
efficiency for fast LC without exhibiting
extremely high back pressure values which can be
obtained with sub-2 μm particles from other
manufacturers. Therefore YMC’s UltraHT Pro C18
may not require dedicated HPLC equipment for
providing outstanding column performances. |
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YMC’s proprietary endcapping and bonding
chemistry combine to contribute outstanding
efficiency along with symmetrical peak shape. |
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YMC hereby acknowledges, to the best of their
knowledge, third party trademarks as follows:
Acquity UPLC BEG C18 is a registered trademark
of Waters Corporation.
Zorbax Eclipse EDB-C18 is a registered trademark
of Agilent Technologies Inc..
Zorbax XDBC-C18 is a registered trademark of
Agilent Technologies Inc.. |
